01:146:328 Lecture Notes - Lecture 12: Duffy Antigen System, Plasmodium Ovale, Plasmodium Falciparum
18 Mar 2016
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Document Summary
Plasmodium vivax: causes approximately 43% of malaria cases. Characteristics: sporozoites occur in two types, short prepatent sporozoite. Remain in hepatocytes during this time they are called hypnozoites. Relapse patient has vivax malaria; recovers and is in normal health. Recurrence of disease years after initial infection due to hypnozoites in liver that escaped and invaded rbcs: merozoites can only penetrate rbc"s that have specific receptor sites on their surface. That receptor site is called a duffy antigen: duffy antigen. Necessary for merozoites to bind and invade. If duffy antigen a (fa) or duffy antigen b (fb) is present merozoite can penetrate. If duffy antigen y (no receptors) merozoite cannot penetrate . Duffy negative individual (cannot become infected resistant to vivax malaria) Duffy antigen y genotype approximately 90% of west african natives and 70% of african americans have it: trophozoites. Schiiffner"s dots another characteristic: fever every 48 hours. Plasmodium malariae: causes 7% of malaria cases, fevers are every 72 hours, ring stage.
