01:146:356 Lecture Notes - Lecture 6: Perfusion, Hyperaemia, Pharmaceutical Industry

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:356
• Professor: Roseli Golfetti

Document Summary

Coronary circulation in the mammalian heart (one example) Oxygen supply to demand, coronary blood flow and the adenosine hypothesis. Other metabolites that contribute to the regulation of coronary blood flow. Because of shear rate those laminae move at different rates/velocity. The laminae with the greatest velocity are near the central axis of the vessel. The laminae with the slowest velocity are near the perimeter of the vessel. Shear force-variable that determines velocity. is greatest at the wall and impede the laminae- and shear force is least at the central axis. One illustrator"s rendition of the epicardial coronary circulation in the mammalian heart. Coronary blood flow in humans originates in aorta. 2 openings in first openings in the aorta: 1st one is coronary austia for the main coronary blood vessels. Naturally, coronary circulation comes directly from aortic blood flow. 75-80% of total coronary blood flow passes through the left main coronary artery. Remaining 20-25% passes through right main coronary artery.