01:377:213 Lecture Notes - Lecture 20: Nuclear Matrix, Nuclear Membrane, Nuclear Pore

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13 May 2018
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I. Membranous Organelles
A. Surrounded by phospholipid membrane similar to plasma membrane
B. The isolation provided by membrane allows organelle to manufacture substances
that could harm cytoplasm
C. Mitochondria
1. Produce ATP (energy currency of cell)
a) Generate ATP by breaking down organic molecules which
consumes oxygen and generate carbon dioxide
b) These chemical reactions produce about 95% energy needed to
keep cell alive
2. Number of mitochondria in a cell varies depending on the cell’s energy
demands. Many shapes
a) RBC-none
b) Skeletal muscle- 300 mitochondra
3. Able to control own maintenance, growth and reproduction
4. Two membranes
a) Inner Membrane
(1) Contains numerous folds called christi
(a) Surround fluid contents or matrix and provide a
large surface area for organization of enzymes that
produce most of ATP
b) Outer membrane
D. Nucleus
1. Control center for cellular operations
2. A single nucleus stores all the info for the synthesis of 100000 different
proteins
3. Determines the structural and functional characteristics of the cell by
controlling which proteins are synthesized, when they are synthesized, and
in what amounts
4. Most cells have single nucleus
a) Skeletal cells are multi nucleus
b) RBC- no nucleus
5. Surrounding the nucleus and separating it from the cytosol is the nuclear
envelope
a) Double layer membrane that encloses a narrow perinuclear space
6. The nucleus directs process taking place in cytosol and recieves info about
conditions nd activities in cytosol
7. Chemical communication between the nucleus and cytosol occurs through
nuclear pores
a) A complex of proteins that regulates the movement of
macromolecules in and out of nucleus
b) 10% of the surface of the nucleus permit the movenet of water,
ions and small molecules that regulate the passage of large
proteins, RNA and DNA
8. Nucleoplasm is a jelly-like fluid substance within the nucleus
a) Network of fine filaments aka nuclear matrix which provides
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