01:377:370 Lecture 11: Transport of glucose
10 Feb 2019
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Document Summary
Transport of glucose into the sarcoplasm for use in glycolysis is dependent on. Responds to elevated insulin (following a high cho meal) Responds to physical activity independent of insulin. Highly dependent on available glycogen (from glycogenesis) Pyruvate (if not used for aerobic glycolysis) may be reduced to form lactate. Allows nad+ to be freed from nadh for reuse in the glycolytic cycle. Ph drops are as proton concentration rises (from nadh) Lactate accumulation, not simply production, signals onset of anaerobic metabolism. If lactate is not used and thus accumulates, fatigue will eventually set in this does not mean that lactate is bad. Lactate produced in ft muscle fibers can be shuttled to other ft or. When oxygen becomes available or when the pace of exercise slows, this pyruvate can be oxidized as an energy source in these other cells. Converted back to pyruvate and then glucose in the liver in cori.
