01:377:370 Lecture Notes - Lecture 22: Carbamino, Carbonic Anhydrase, Globular Protein
11 Apr 2019
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2,3 dpg is a by product of glycolysis from rbc. Binds loosely to hb reducing its affinity for o2. Causes greater o2 release to the tissues. 2,3 dpg increases with intense exercise and may increase due to training (as well as altitude) Females have higher 2,3 dpg levels than men of similar fitness status/activity level; may help compensate for the lower hb. Myoglobin is an iron-containing globular protein in skeletal and cardiac muscle. Facilitates transfer of o2 to the mitochondria, particularly when exercise begins and during intense exercise when cellular po2 rapidly declines. Not an s shaped dissociation curve like hb. Myoglobin actually binds and retains o2 at low po2 more readily than hb. ~5% co2 is transported as dissolved co2. The dissolved co2 establishes the pco2 of the blood. Carbonic anhydrase facilitates the formation of the bicarbonate (h2co3) When hco3- moves into the plasma, cl- moves into the rbs to maintain ionic equilibrium (chloride shift)
