14:440:301 Lecture 5: Pharmaceutical Chemistry Dr Hu Lecture Five
30 Oct 2014
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Document Summary
H1 is related to allergy receptor in brain and associated with drowsiness. H2 receptors relate to acid production in stomach, used to treat ulcer and gerd and its mechanism based to inhibit production of these acids. H3 known to be an auto receptor and inhibit the release of histamines. We looked at aromatic hydroxylation and how it has an intermediate and the product is the hydroxyl introduction to para position of substituent. One way to inhibit metablic reaction by adding electron withdragin groups such as chlorines and fluorines. Oxidative dealkylation reaction which goes through carbenolaemn intermediate. If its deaminiation, same carbinolamine is also used and the product is a ketone contiaing product. We looked at hetero atom containing oxidations with ethers. Sulfer ethers can undergoe oxidative dealkykation and deamination. All these reaction you need alpha hydrogen attatched to alpha carbon that needs to be insterted with oxygen. You need to know product through a mechanism.
