01:447:390 Lecture Notes - Lecture 20: Carbapenem, Dna Gyrase, Quinolone
Document Summary
Fungi pose special problems for chemotherapy because they are eukaryotic. Cell wall synthesis: polyoxins inhibit chitin synthesis. Membrane function: polyenes bind to ergosterol and disrupt membrane integrity. Antimicrobial drug resistance: the acquired ability of a microbe to resist the effects of a chemotherapeutic agent to which it is normally sensitive, cre: carbapenem resistant enterobacteriaceae, picture: left plate has a lot of resistance. Bacteria can acquire resistance from taking up a new plasmid- there is a gene on a plasmid that gives the bacteria some new capability. This gene in the plasmid may have been around for a long amount of time or it can be a synthetic gene. Bla gene: beta-lactamase gene, use this to select for transformed cells. At least five reasons that microorganisms are naturally resistant to certain antibiotics: organism is impermeable to antibiotic (ex. Carbapenem used to be able to get inside cells, now it: organism can inactivate the antibiotic (ex.
