01:447:390 Lecture Notes - Lecture 24: Reverse-Transcriptase Inhibitor, Reverse Transcriptase, Blood-Borne Disease

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29 Dec 2015
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Hepatitis a virus (infectious hepatitis: causes mild or rarely, severe lever disease (fecal/oral; enterovirus), it can be acquired from contaminated water, vaccine; children, travelers, picornavirus: small rna virus, causes acute, often severe disease. Hepatitis b virus (serum hepatitis): hepadnavirus (hepa-dna; has a dna genome) Ranges in severity from a mild illness, lasting a few weeks (acute), to a serious long-term (chronic) illness that can lead to liver disease or liver cancer: hepadnavirus (partially ds dna) Most infected people do not know that they are infected. Uses reverse transcriptase- replicate their genome via a plus sense rna intermediate, using reverse transcriptase. Vaccination: hepatitis b vaccination is recommended for all infants, older children and adolescents who were not vaccinate previously, and adults at risk for hbv infection. Treatment: reverse transcriptase inhibitor (target the reverse transcriptase!) Short answer: targeting viruses for treatment of the disease. Hcv infection sometimes acute, most often becomes a chronic condition- can lead to cirrhosis and liver cancer.

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