01:694:301 Lecture Notes - Lecture 15: Nicotinamide Adenine Dinucleotide Phosphate, Flavin Adenine Dinucleotide, Flavin Group
Document Summary
Chapter 15 metabolism: basic concepts and design": metabolism is a linked series of chemical reactions that begins with x molecule and converts molecule to y, z, etc. In careful defined fashion": metabolic pathways can be divided into two divisions: 1) those that convert energy from fuels into biologically useful forms: catabolism break down"; generation of atp. Gain of electrons: note the different h-atom forms, h+ protons (0e-) H hydride ion (2e-: know how all of these cofactors are used in the cell, and that they come from vitamins, during oxidation fuel molecules transfer their e- to special carriers" (pyridine nucleotides of flavins). The reduced forms of these carriers then transfer high potential e- to o2. Fad, fadh2 flavin adenine dinucleotide: reactive part of fad is isoallazine ring (vitamin riboflavin, can also accept 2e- but also takes up 2 protons. Fmn, fmnh2 flavin mononucleotide (lacks adenine compared to fad: activated carrier in reductive biosynthesis.