01:694:301 Lecture Notes - Lecture 17: Acetyl-Coa, Thiamine Pyrophosphate, Oxidative Decarboxylation

• School: Rutgers University
• Department: Molecular Biology and Biochemistry
• Course: 01:694:301
• Professor: F Deis

Document Summary

Final common pathway oxidation of fuel molecules carbs, fatty acids, aa. Most fuels enter cac as acetyl coa: most atp provided is from the aerobic processing of glucose cac. Function of cac is to harvest high energy electrons from these carbon fuels. Catalyzed pyruvate dh component (e1: 2) oxidation hydroxylethyl group is oxidized to form acetyl group; at same time transferred to lipoamide form energy rich thioester bond. Catalyzed pyruvate dh component (e1: 3) formation of acetyl coa - acetyl group is transferred from acetyllipoamide to coa sh. Catalyzed dihydrolipoyl transacteylase (e2: 4) regeneration of oxidized form of lipoamide 2 e- transferred to fad and then nad+ Catalyzed dihydrolipoyl dh (e3: understand how lipoamide functions both as a redox cofactor and a delivery system (501) Swinging cofactor": closed ring oxy open ring red. Long, flexible arm of lipoamide on e2 subunit carries substrate from active site to site.