11:709:255 Lecture Notes - Lecture 7: Alcohol Dehydrogenase, Fetal Alcohol Spectrum Disorder, Vitamin B6

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Alcohol: alcohol tid-bits, chemically known as ethanol, 7 kcal/g. Liver damage: with excess alcohol consumption there is a buildup of acetaldehyde, production of free radicals from alcohol metabolism, early stages are reversible. Effects on water soluble vitamins: thiamin deficiency, niacin deficiency, vitamin b-6 deficiency, vitamin b-12, folate deficiency, vitamin c. Effects on vitamin a: reduces intake, liver cant produce carrier proteins, effects on vitamin d, bones. Other fat soluble vitamins: effects of vitamins k and e related to alcohol damaged pancreas, reduced fat absorption, vitamin k, affect vitamin k dependent blood clotting factors, vitamin e, leads to development of peripheral neuropathy and tunnel vision. Effects on minerals: magnesium deficiency, zinc deficiency, iron deficiency. Xiii: avoidable, deprived brain of oxygen and nutrients, ~4 drinks a day or binge drinking while pregnant. Dependency: children of alcoholics are 4x more likely to become alcoholics, higher rates in men. Cage questionnaire: c: cut, a: annoyed, g guilty, e: eye opener.

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