01:830:364 Lecture Notes - Lecture 15: Racemic Mixture, Major Depressive Disorder, Chemical Synapse
Document Summary
Amphetamine increases da release in nac by: Reducing the rate of enzymatic breakdown of da by mao. Increasing the density of the monoamine substrates in the presynaptic terminal available to be acted upon by maos. Amphetamines were used to treat clinical symptoms of depression. Amphetamines were used by the military to banish fatigue and increase mental alertness and vigilance of those on guard duty. Forms of amphetamine stereo-optical isomer) l- amphetamine (levo or left-hand stereo-optical isomer) d-amphetamine (dextro or right-hand. Adderal (cocktail of amphetamine salts) dl- amphetamine (racemic mixture) High lipid-solubility enables more rapid accumulation across blood- brain barrier. Amphetamine-type stimulants: estimated 12-month prevalence is 0. 2%, 4 times. Prevalence higher for females than males, and 4 times higher for 18-29 year olds than 45-64 year olds. Estimated past-year unprescribed use was approximately 7% for high school age or younger, and 30% for college age persons. Sedatives are taken to reduce insomnia, nervousness, agitation, and other unpleasant side effects.
