01:830:364 Lecture Notes - Lecture 13: Intraocular Pressure, Cannabinoid, Multiple Sclerosis

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13 Mar 2018
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The effects of marijuana (cannabis) are caused by cannabinoids, notably delta-9- Smoking marijuana introduces other similar compounds (analogues and metabolites of thc) that also contribute to its spectrum of effects. Cannabinoid receptors (cb1 and cb2) and endogenous cannabinoids (anandamide and 2-ag) were discovered in 1990. The cb1 receptor is widely distributed in the brain and mediates most of the psychological effects of thc. Marijuana induces a high described as a feeling of relaxation combined with a sense of well-being or euphoria. Thc induces euphoria by increasing da release in the nac. thdr da fibers do not have cb, receptors, but thc binds to cb receptors on gaba interneurons, removing their tonic inhibitory effects on da activity. The dea classifies marijuana as a schedule i drug. Multiple sclerosis (reduce muscle spasticity and seizures). Marijuana"s acute effects are not prominent several hours after smoking,

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