01:830:338 Lecture Notes - Lecture 5: Jeanne Calment, Maximum Life Span, Hayflick Limit
28 May 2016
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Document Summary
Free radicals: by-products of normal metabolism and response to environment. Resistance to and repair of potentially damaging chemical reactions decline with age. Every species has characteristic maximum life span set by genetic program. Hayflick limit = number of cell divisions species undergo before reaching replicative senescence. Primary aging occurs when species limit is approached. Limit on number of calories metabolized per day. Both men and women gain weight in young adulthood and middle adulthood, losing late in the 50s, but in slightly different patterns. Skin: wrinkles due to redistribution of body fat and loss of elasticity. Treatment with tretinoin and medical procedures somewhat effective. Looking younger may be related to feeling younger. Loss of pupil effectiveness and decline in ability to accommodate = reduction in visual acuity. Cataracts: clouding of lens that reduces sharp transmission to retina. Glaucoma: pressure buildup inside eye that destroys optic nerve. Age-related macular degeneration: retina disorder causing central vision loss.
