MLS 301 Lecture Notes - Lecture 7: Hemolytic Anemia, Reticulocyte, Clinical Urine Tests
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Background
A 10-month-old Central American child was referred to the laboratory for testing after being seen by a pediatrician. The phlebotomist noted that the child was very pale and listless. The following tests were ordered: CBC with platelet, reticulocyte count, total serum bilirubin, total serum iron, and total iron-binding capacity (TIBC), as well as a stool examination for occult blood, ova, and parasites. The results are listed below:
Parameter | Result | Reference Range |
Hemoglobin | 5.6 g/dL | 10.5-13.5 g/dL |
Hematocrit | 24% | 33-42% |
RBC | 3.5 x 1012/L | 3.7-5.3 x 1012/L |
WBC | 10.5 x 109/L | 6.0-18.0 x 109/L |
Platelet | 200 x 109/L | 150-450 x 109/L |
MCV | 68.6 fL | 74-91 fL |
MCH | 16 pg | 23-31 pg |
MCHC | 23% | 32-36% |
Retic count | 0.5% | 0.5-2.0% |
Total serum bilirubin | 0.9 mg/dL | 0.3-1.9 mg/dL |
Serum iron | 40 µg/dL | 50-160 µg/dL |
Serum ferritin | 5 ng/mL | 15-400 ng/mL |
TIBC | 465 µg/dL | 250-400 µg/dL |
% Saturation | 8.6% | 20-55% |
The stool examination was negative for occult blood, ova, and parasites.
What kind of erythrocyte morphology would you expect to observe in the peripheral blood of this patient?
What would the bone marrow look like in this patient if we stained a slide with Wrightâs Stain? And with Prussian blue?