MLS 341 Lecture Notes - Lecture 4: Hib Vaccine, Brazilian Purpuric Fever, Haemophilus Ducreyi
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Objectives: upon completion of this lesson, the student will be able to: Describe the general characteristics, virulence factors, clinical infections and laboratory tests utilized to differentiate the following organisms. (be able to create identification algorithms). Aerobic gram-negative bacilli (coccobacilli) haemophilus spp. (h. influenza, h. aegyptius: parahaemolyticus, h. haemolyticus, h. parainfluenzae, h. paraphrohaemolyticus, h. pittmaniae, h. sputorum, h. ducreyi, aggregatibacter aphrophilus) and other commensals within the genus listed. Explain the principle of the delta-aminolevulinic acid (ala) test. Detects enzymes that convert -amino-levulinic acid (ala) into porphyrins. Describe the antigen used to serotype haemophilus influenzae and what non-typeable strains indicate: inluenza. Third generaion cephalosporins (cetriaxone and cefotaxime) may be efecive. Lacatamase strains have elevated mic to ampicillin, amoxicillin and some cephalosporins. Describe the haemophilus influenzae vaccine including the biochemistry, recommendations for use and clinical efficacy. Define x and v factors and explain the use for the identification and differentiation of.
