BIO 212 Lecture Notes - Summer 2018 Lecture 5 - Estriol, Follicular phase, Oogenesis

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Summary of reproductive physiology: genetic sex is determined by the sex chromosomes, either xx or xy. Gonadal sex is defined by the presence of testes or ovaries. Phenotypic sex is determined by the hormonal output of the gonads: puberty in males and females is initiated by the pulsatile secretion of gnrh, which drives the pulsatile secretion of. Pulsatile secretion of fsh and lh drives the testes and ovaries to secrete their respective sex steroid hormones (testosterone, and progesterone and estrogen): in males, the testes are responsible for spermatogenesis and secretion of testosterone. Testosterone is synthesized from cholesterol by the leydig cells. In some target tissues, testosterone must be converted to dihydrotestosterone by the action of 5 -reductase. Progesterone and 17 -estradiol are synthesized from cholesterol by theca and granulosa cells, respectively. Theca cells synthesize progesterone and testosterone, and granulosa cells convert testosterone to.

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