ENS 332 Lecture Notes - Lecture 18: Lateral Globus Pallidus, Medial Globus Pallidus, Substantia Nigra
29 Nov 2016
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Document Summary
Prevalence: up to ~300 cases per 100,000 people in the us (0. 3% of population) Variability depending on location in the world: ~1% of population over 60 years. There is an age effect: ~5% of people diagnosed <50 years. Relatively rare to have early onset: hard to say if there are regional differences, might be noise in the data, ~7-10 million worldwide. Incidence: ~8-18 new cases per 100,000 person years, but with a strong age-effect, some data show more common in men, although inconsistent. The effect may be something like 1. 5x more likely. Some inconsistency in the prospective study data where men and women"s risk comes close together. Costs: billion per year us, . 5k per year in meds per person, ~,000 per therapeutic surgery. Mortality and morbidity: hazard ratio for death between 1. 5 and 2. 7, possibly mediated via dementia, mortality risk is modest in pd patients who no not develop dementia, 25-40% of pd patients develop dementia.
