PHYS 799 Lecture Notes - Lecture 38: Pattern Recognition Receptor, Regulatory T Cell, Cytotoxic T Cell
7 Jun 2019
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Innate immunity genetically fixed, pattern recognition, immediate response, no learning/memory. Adaptive immunity specific, learning and memory, takes time to develop. Innate humoral = complement; innate cellular = phagocytes. Adaptive humoral = antibodies (b cells); innate cellular = t cells. Phagocytes destroy pathogens and debris (neutrophils, macrophages), present antigens (dendritic cells) Dendritic cells process ingested antigens and present peptides on mhc molecules to t cells. Innate cells and complement proteins express pattern recognition receptors (prrs) that recognize pathogen associated molecular patterns (pamps) B cells make antibodies; neutralize toxins, block viral infection, promote phagocytosis, activate complement, activate immune cells. Cd4 = t helper cell activate cells, produce cytokines; cd8 = cytotoxic t cell, migrate and kill infected cells; regulatory t cell = turn off immune response. Cytokines 3 types: inflammatory, hematopetic (stimulate immune cell production/growth), regulatory (regulate cell phenotype/activity) there are regulators of innate and adaptive. Costimulatory molecules cell surface molecules that activate/inhibit other cells.
