MATH 221 Lecture Notes - Lecture 16: Ernest Mcculloch, Primordium, Imaginal Disc
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Example is notch --- she just said know this: off, on. Self renewal and potency used with stem cells. Stem cells cannot be used with progenitor cells. A) single cell asymmetry: fit can make more stem cells while also making cells committed to undergoing differention. B) population asymmetry: stem cell can divide symmetrically to make either two stem cells (increasing stem cell pool by one) or two committed cells (decreasing pool by one) symmetrical renewing or symmetrical differentiating. They used two different mice and eradiated the mice, destroying vascular system. Then, injected bone marrow cell in the mice. After 10 days, they sacrificed mice and looked at the spleen. There were colonies on spleen which had precursor for rbcs, wbcs and platelets. They were able to discover hematopoietic stem cells. Hippo important for cell proliferation, stem cell removal, apoptosis and organ size. When hippo pathway off: yap goes into nucleus and turns on genes for cell differentiation.