PHSL 310 Lecture Notes - Lecture 11: Voltage-Dependent Calcium Channel, Neurotransmitter Receptor, Axon Terminal
Document Summary
Lecture 11: physiology 310: process of nt release, action potential reaches the axon terminal, voltage gated ca2+ channels open (depolarizing, calcium enters the axon terminal, ca2+ binds to proteins associated with synaptotagmins (a vesicle) They will bind to a receptor, allowing for opening/closing of ligand gated channel. Chemical synapses: excitatory: depolarization occurs, going towards threshold (net movement of ions is into post synaptic) excitatory postsynaptic potential (epsp) Inhibitory: postsynaptic is hyperpolarizing inhibitory post synaptic potential (ipsp: cl/k+ channels open, na+ not relevant, cl will hyperpolarize, make cell more negative via active transport. If no channels present, cl- at equilibrium will be equal to resting potential: stimulating presynaptic releasing an nt open cl- channels, no effect on, stabilization can also occur; also hyperpolarize. postsynaptic. 6. 5 synaptic integration: temporal summation: when input signals arrive from presynaptic at different times, so you many signals reaching axon terminal many times, just keeps going, Initial segment: negative (lowest) threshold, high na+, threshold when.
