PHSL 310 Lecture Notes - Lecture 2: Androstenediol, Pituitary Gland, Peptide
Document Summary
Gastrin (17 aa), glucagon (32 aa), calcitonin (32 aa), adrenocoticotropic (39 aa), a/b melanocyte stimulating hormone (11, 18, 22 aa) Tsh, fsh, mineralocorticoids, progesterone, androgens, estrogen, vitamin d. Endocrinological investigation: extirpate putative gland, describe effects of operation, inject gland extract, demonstrate, injection of extract can reverse defects of operation, isolate-purify- identify, Steroid (testosterone, estrogen, progesterone: water soluble, membrane receptor. Single peptide/prohormones used: making is rare, storage is significant, degradation is inactive, half-life short (min, rare plasma binding proteins. Cytoplasm receptor: translocate to the nucleus, nuclear receptor, many enzymes used. Stimulates mrna making: making is common, storage is minimal, degradation sometimes, half-life (long hrs. ) Lots of plasma binding proteins: long loop: gonad hormones will inhibit hypothalamic/hypophyseal hormones (3 hormone sequence, short loop: pituitary hormone inhibits hypothalamic hormone, ultra-short loop: hypothalamic hormones feedback on itself, negative feedback systems inhibit and positive feedback facilitate.
