PHSL 410B Lecture Notes - Lecture 4: Atp Hydrolysis, Myoglobin, Endergonic Reaction
Document Summary
Atp hydrolysis drives cellular endergonic processes: the terminal phosphate can be transferred to aa, lipids, sugars, proteins, process: phosphate transfer from atp above receptor removed in second step. & are needed for everything also found that enzymes responsible for every metabolic reaction. James sumner crystallized urease from jack beans found it was protein but then rna enzymes (ribozymes) were discovered and was believed it was used for protein catalysts. Enzymes: enzymes can be conjugated proteins with nonprotein component that carry out activities for which. Models of enzyme action: lock and key (emil fischer)- enzyme rigid fit. Induced fit (daniel koshland)- flexible, alters shape with substrate, may move r groups. Mechanisms of enzyme catalysis: substrate orientation: enzyme will take substrate out of sln and hold them to catalyst surface lowering entropy. It will bind substrates close and in right orientation. Inducing strain in substrate- can change shape, bonds may break.
