PSYC 301 Lecture Notes - Lecture 8: Phospholipid, Troponin, Jerky
Document Summary
Chapter 19 control of gene expression in eukaryotes. Higher level of dna packing: beaded string coils form the 30 nm chromatin fibers, form looped domains attached to a scaffold of non- histone proteins, chromatin occupies a restricted ranged within the nucleus. Interphase chromosomes: chromatin: heterochromatin: tightly compacted, on nuclear envelope- pore rich, along telomere, euchromatin: less compact, and has gene rich regions. Increase transcription: may be located upstream or downstream from the genes they regulated, silencers: dna regulatory regions to which repressors can bind inhibiting transcription, promoter-proximal elements: located close to the promoter to which regulatory proteins bind. Figure 19. 50: enhancer are located upstream/downstream, ppe- right next to promoter. Linking cancer with defects in gene regulation: p53: prevents cancer, transcription factor acts as tumor suppressor and has been shown to be abnormal in many types of cancer, can induce of apoloysis- guardian of genome.
