BIO 1000 Lecture Notes - Lecture 11: Nuclear Membrane, Nuclear Pore, Nuclear Lamina

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The nucleus contains most of the genes in a eukaryotic cell. Additional genes are located in mitochondria and chloroplasts. The nucleus averages about 5 microns in diameter. The nucleus is separated from the cytoplasm by a double membrane called the nuclear envelope. The two membranes of the nuclear envelope are separated by 20 40 nm. The envelope is perforated by pores that are about 100 nm in diameter. At the lip of each pore, the inner and outer membranes of the nuclear envelope are fused to form a continuous membrane. A protein structure called a pore complex lines each pore, regulating the passage of certain large macromolecules and particles. The nuclear side of the envelope is lined by the nuclear lamina, a network of protein filaments that maintains the shape of the nucleus. There is evidence that a framework of fibers called the nuclear matrix extends through the nuclear interior.

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