BIO 202 Lecture Notes - Lecture 6: Fluid Mosaic Model, Lipid Bilayer, Membrane Lipids

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Plasma membrane vs. cellular membranes - mitochondria, chloroplasts. Differences based on the functions of the organelles. Allows some substances to cross it more easily than others. Glycoproteins and glycolipids - glycosylated - have hydroxyls which make them hydrophilic. Sticky - interact with other cells and the ecm. Lipids include phospholipids and sterols - cholesterol and phytosterols (plants) Membrane lipids and membrane proteins are amphipathic - have both hydrophilic and hydrophobic regions. Because the cellular membrane has both polar/nonpolar ends - the lipids and proteins have both of these regions. Plasma membrane is thin - needs electron microscope - 5- 8 nm. Two layers of phospholipids - thicker than 1 nm. Proposed in 1972 by singer and nicolson. Arranged proteins and lipids in a way that accommodated for the amphipathic regions. Found that the 20 or so amino acid actually traversed the entire membrane.

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