BIO 315 Lecture Notes - Lecture 8: Corynebacterium Diphtheriae, Streptococcal Pharyngitis, Lymphadenopathy

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Lecture #8: microbial diseases of the respiratory system, structure and function of the respiratory system, upper respiratory system. Hairs in the nose filter large dust particles from the air. Saliva and tears protect mucosal surfaces: lower respiratory system. Ciliary escalator moves particles toward the throat via ciliary action. Respiratory mucus protects mucosal surfaces: microbial diseases of the upper respiratory system, pharyngitis (sore throat) most common infection, laryngitis, tonsillitis, sinusitis, epiglottitis (most life threatening disease of the upper respiratory system) Bacteria, not viruses, opportunistic pathogens, can be present in the throat in small numbers, do not overgrow due to normal microbiota: normal microbiota of the respiratory system. Normal microbiota suppress pathogens by competing for nutrients and producing inhibitory substances. Lower respiratory system is nearly sterile: bacterial diseases of the upper respiratory system, streptococcal pharyngitis (strep throat) Caused by group a streptococci (gas: streptococcus pyogenes, resistant to phagocytosis, streptokinases lyse clots, streptolysins are cytotoxic. Diagnosis by enzyme immunoassay (eia) tests: scarlet fever.

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