BIO 121 Lecture Notes - Lecture 12: Erwin Chargaff, Frederick Griffith, Dna Replication

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22 Jan 2018
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The base composition of dna varies between species: 2. In any species the number of a and t bases is equal and the number of g and. Dna replication: semi-conservative model, a). parental molecule, b). separation of parental strands into templates, c). formation of new strands complementary to template strands, replication begins at particular sites called origins of replication, where the 2. Dna stra(cid:374)ds are separated, ope(cid:374)i(cid:374)g up a repli(cid:272)atio(cid:374) (cid:862)(cid:271)u(cid:271)(cid:271)le(cid:863: a eukaryote chromosome may have hundreds or even thousands of orgins of replication, at the end of each replication bubble is a replication fork, a y-shaped region where new. Replication begins at origins of replication: 2. Initiation proteins bind to origins of replication and separate two strands, forming the replication bubble: 3. Dna polymerases catalyze elongation of new dna at replication fork: 4. Dna polymerase adds nucleotides one by one in a (cid:1009)" to (cid:1007)" dire(cid:272)tio(cid:374: 5. Leading strand: repli(cid:272)atio(cid:374) o(cid:272)(cid:272)urs alo(cid:374)g (cid:1009)" to (cid:1007)".

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