BIO 121 Lecture Notes - Lecture 12: Dna Ligase, Okazaki Fragments, Erwin Chargaff
23 Mar 2018
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Document Summary
1953: double-helix model for the structure of dna acid or dna. Hereditary information is encoded in dna and reproduced in all cells of the body. Dna is copied during dna replication and cells can repair their dna. Frederick griffith: the role of dna is hereditary was first discovered by studying bacteria and the viruses that infect them. Avery mccarty and macleod: in 1944 conducted transforming agent from griffith"s work was dna. 1952: hershey and chase: bacteriophages and radioactive tags experiment. 1950: erwin chargaff reported that dna composition varies from one species to the next. The base composition of dna varies between species. In any species and the number of a and t bases are equal and the number of c and g are equal in number. (same proportion) Pairing a purine ( a and g) with a pyrimidine (c and t) resulted in a uniform width consistent with the x-ray data. Antiparallel: strands and subunits run in opposite directions.
