NSD 225 Lecture Notes - Lecture 12: Nutrigenetics, Nutrigenomics, Beta-Carotene

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Our growth, development and maintenance of cells are directed by our genes. Inherited changes in gene expression caused by mechanisms other than changes in the underlying dna sequence. This involves the study of the interaction between nutrients and genes at the molecular level. Studies the relationship among genes, nutrients and health outcomes (disease). A person"s genetic sequence affects his or her nutrient requirements, energy utilization, appetite and taste, and risk of chronic disease in response to diet. Cardiovascular disease: gene-environment interaction, 1 in 500 americans have a genetic defect in the way they process cholesterol. Obesity: at least 60 genes have been identified as being involved in regulation of body weight. Diabetes: more than 200 genes identified as associated with development and/or incidence of diabetes, strong link to obesity. Cancer: strong genetic link in certain types of cancer. Genetics information and nondiscrimination act (gina) 2008: prohibits health insurers for raising premiums or denying coverage based on genetic information.

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