NSD 481 Lecture Notes - Lecture 8: Hypermetabolism, Protein Catabolism, Fluid Replacement

49 views15 pages

Document Summary

How is the metabolic response to critical illness similar to starvation. Metabolism goes up in illness starvation it goes down. Pt is nutritionally (cid:494)at risk(cid:495) when he/she is at risk for poorer outcome than if she/he was not malnourished. Three phases: ebb phase (2-48 hours, flow phase (next, recovery. Proteins in liver that are synthesized in response to injury and infection. Stimulate kidneys in order to preserve fluid and sodium retention. Get fluid and salt conservation (supports blood volume) reduction in urine output. Restore blood flow to organs; want fluid in= fluid out. Marked increase in glucose production and ffa release. High circulating levels of epi/norepi, glucagon, and cortisol. Elevated levels of (cid:498)counterregulatory(cid:499) (cid:523)raise blood sugar(cid:524) or stress hormones. Promotes gluconeogenesis, aa uptake, ureagenesis (have to get rid of nitrogen/protein), and protein catabolism. Promotes gluconeogenesis, glycogenolysis (breakdown glycogen), and acute-phase protein synthesis. All stored glucose depleted in ~24 hour all patients that are ill will develop hyperglycemia.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents