PSY 315 Lecture Notes - Lecture 7: Nmda Receptor Antagonist, Ketamine, Diazepam
Document Summary
Acetylcholine (ach) - stimulates muscle contraction (pns), pupil constriction, and gastrointestinal mobility. Periphery = stimulatory found on all neuromuscular junctions of skeletal muscles. Inhibitors: dfp (diisopropyl fluorophosphates) keeps muscles depolarized, unable to contract paralysis, asphyxiation, nerve gas during wwii, physostigmine: short-acting, reversible ache. Only indirect agonists affect all cholinergic receptors: direct agonist/antagonists attach directly to receptors, thus distinguishing between nicotinic and muscarinic receptors. Initially nicotine activates ach receptors, but too much cannot be metabolized/takes over receptors: nicotinic receptors in somatic ns, synapses at ans, noncompetitive antagonist: curare only on nicotinic receptor (peripheral, steals receptors, prevents ach in muscles conscious, paralyzed. Serotonin (5-ht) (inhibitory) = mood-elevating, appetite, social behavior, sleep. 98% of 5-ht is in periphery (blood, smooth muscles of gi tract) Begins as tryptophan (protein: rise in anticipation of food and spike during meal. Serotonergic somae lie mostly in raphe nuclei of upper brain stem. Increase carbs increases blood tryptophan increase serotonin, elevates mood (food chemically makes u happy)
