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Lecture 7

BIMS 201 Lecture Notes - Lecture 7: Caat Box, Tata-Binding Protein, Histone H3

Biomedical Science
Course Code
BIMS 201
Elizabeth A.Crouch

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Chapter 17 Notes
Spatial and temporal regulation (made in right tissue @ right time for multiple
Promoter region picture: transcription happens from left right
TAFII250: 250=MW (kilodalton), transcription associated factor
Transcription factor=front-line for initiating transcription
Protei has  subuits do’t have to eorize
o TATA binding protein (TBP): binds in minor groove bend DNA help open up
Histone acetylase associated w/it (adds acetate (-) to histone H3 or H4)
repels DNA bc both charge
10 subunit protein attracts RNA pol II to it
sugar-phosphate backbone=why DNA is neg. charged
GC box: series of G’s ad C’s ad CCAAT box
o Have proteins that INC bending of DNA
Hox proteins turn on limb dev. in coordinated manner
o Located on 4 diff. chromosomes (located in same pt. of nucleus)
o Turned on sequentially on chromosome
Dep. on combination of promoters can make many diff. proteins many diff. cell types
Enhancer sequences: can activate/repress transcription
o Called architectural proteins when bind bc change architecture of DNA
o Global: silencing entire region of chromosome
Usually thru epigenetic mechanism (methylation); make chromosome
heterochromatic (turned off)
Skip insulators
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