BICH 410 Lecture Notes - Lecture 7: Structural Level, Porphyrin, Fetus

• School: Texas A&M University
• Department: Biochemistry
• Course: BICH 410
• Professor: Chavela M Carr

Document Summary

Fe ta l hb ha s (cid:534) not (cid:533), doe s not bind bp g, s o tighte r o2 binding. S ickle -ce ll ane mia: a molecula r dis e as e of hb: glu -> va l mutation in (cid:533)-s ubunit le a ds to a ggre ga tion, polyme rs. S e le ctive pre s s ure for hb s is s urviva l of ma la ria: hb s polyme rs ca us e s ickling of re d blood ce lls , a ne mia. Individua l a lpha he lice s a re s e conda ry s tructure: h bonding; ba ckbone bonding. S igmoida l curve: a fifth liga nd is dona te d by the imida zole s ide cha in of amino a cid. Iron inte ra cts with s ix liga nds in hb a nd mb.