GENE 320 Lecture Notes - Lecture 10: Chromosome, Microrna, Small Nuclear Rna
Document Summary
Replicate store information express information allow variation by mutation. Experiments that allowed for the identi cation of dna: Grif th"s transformation experiment virulent = dead avirulent = alive heat killed = alive. Injected avirulent and virulent strains of bacteria into a mouse and documented what happened to the mouse afterwards. Combination of heat killed and avirulent = dead mouse. Transforming principle could be part of polysaccharide capsule or compound required for capsule synthesis avirulent -> virulent. Dnase utilized to destroy transforming activity (destroys dna) This demonstrated that the transforming principle was dna and not protein. Demonstration wasn"t enough to con rm that dna was the genetic material* Demonstrated that dna, not protein is the genetic material. Demonstrated dna enters bacterial cell during infection an directs viral reproduction. C = g - triple bond more g/c = stronger bonds and the more energy required to break it apart. G + c content varies widely across species*
