GENE 320 Lecture Notes - Lecture 15: Dna Mismatch Repair, Ames Test, Proofreading
Document Summary
Results in new triplet code for different amino acid result in triplet code for stop condon (translation terminated prematurely) Silent mutations (synonymous mutation) new triplet code still codes for same amino acid. Pyrimidine replaces pyrimidine or purine replaces purine purine and pyrimidine are interchanged more likely to change the amino acid type. Result from insertions or deletions of base pair. Loss or addition of nucleotide causes shift in reading frame. Frame of triplet reading during translation is altered. Can change the function of the entire sequence depending on. Can change the function of the entire sequence depending on where and if a insertion/deletion takes place. Classi ed by phenotype: reduces/eliminated function of gene product. Results in gene with enhanced, negative, or new function interrupt essential process and result in death various inherited biochemical disorders. Gene product functions at one temperature but not another. Ex: temperature sensitive coat color variations in siamese cats and himalayan rabbits.
