GENE 320 Lecture Notes - Lecture 18: Hereditary Nonpolyposis Colorectal Cancer, Chronic Myelogenous Leukemia, Xeroderma Pigmentosum
Document Summary
Translational and posttranslational regulation p53 protein p53 levels increase if cell suffers dna damage or metabolic stress p53 is a transcription factor that induces transription of mdm2 gene (ubiquitin ligase, blocks transcription) Ubiquitin tags proteins for degradation by enzymes very conserved proteins found in eukaryotic cells main function is to target other proteins for destruction. Once attached to protein, it signals the degradation of the protein. Short rna molecules regulate gene expression in cytoplasm of plants, animals, and fungi; repress translation and trigger mrna degradation. Known as rna induced gene silencing therapeutic rnai attacks diseases caused by overexpression of speci c gene or normal expression of abnormal gene product. Potential use in diagnosis of cancers decreases severity of infections by viruses such as hiv, in uenza. The mirna precursor folds back on itself, held together by hydrogen bonds. An enzyme called dicer moved along the double stranded rna, cutting it into shorter segments.
