NRSC 335 Lecture Notes - Lecture 10: Native American Church, Nucleus Accumbens, Local Anesthetic
6 Mar 2017
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Facilitates postsynaptic g aba receptors: anxiolytic-sedative effects. Drugs of recreational abuse (legal: alcohol, marijuana, thc (tetrahydrocannabinol, agonist for cannabinoid receptors. S edative-hypnotic effects: r ecent studies - adolescent iq levels can be affected (prefontal cortex changes? ) C ocaine: e nhances ne and da life in synapse (blocks ne and da reuptake) Local anesthetic: numbing, o d fatalities from seizure or tachycardia, methamphetamine, both yield euphoria and psychomotor activation, nucleus accumbens reward centers. Ls d (lysergic acid diethylamide: activated postsynaptic serotonin receptors, vivid hallucinations - psychedelic. S imilar action to ls d: vivid hallucinations. Mixed (stimulants, hallucinogens: activates 5-ht receptors (like ls d, e uphoria, hallucinations, neurotoxic. Increases inhibition: anxiolytic-sedative effects (overdose is common) Other psychoactive drugs: r ohypnol - date rape drug, g hb - gamma-hydroxybutyrate, heroin, mp tp - bungled synthesis. S ame properties as rohypnol: both can be deadly when combined with alcohol (synergism) S ynthesized from morphine (poppy: activates opioid receptors (like morphine)
