In breast cancer there is an over-expression of the Her2/ErbB2/Neu receptor. Please explain the method of action for the medication trastuzumab (Herceptin) on the Her2/ErbB2/Neu receptor.
What is c-Cbl? What is c-Cbl role in the interaction with the ErbB2/Her2/Neu receptor in the mechanism of action of trastuzumab (Herceptin)?
In prostate cancer PSA is used to determine if a man may or may not get prostate cancer. If you were a scientist what other ways would you use to determine a mans probability of being diagnosed with prostate cancer.
If you were trying to cure prostate cancer, name the receptor you would target.
Draw a picture of a receptor for activated kinase (RTK). Please show dimerization and where phosphorylation occurs and which residues get phosphorylated.
When there is a deletion of a tumor suppressor gene, why does that under-expression of that tumor suppressor gene ultimately cause cancer?