VIBS 204 Lecture Notes - Lecture 4: Salmonellosis, Kwashiorkor, Trichinella

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magentaminnow981

21 Aug 2016

School

Texas A&M University

Department

Vet Integrative Biosci

Course

VIBS 204

Professor

Russell

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Document Summary

Food toxicology and safety (vibs 204) unit 4. The study of health and disease in populations. The study of disease patterns in populations. The study of distribution and determinates of health-related states or events in specified populations and the application of this study to the control of health problems. Frequency- the qualification of the occurrence of a specific disease. Distribution- information about who, when, and where the disease occurs. Determinant- any factor or event that causes a change in health; must know the frequency and distribution to determine. Epidemic- the occurrence in a community or region of cases of an illness, or other health-related event, clearly in excess of the normal expectancy. Endemic- a) the constant presence of a disease or etiologic agent in a given area or b) the usual prevalence of a given disease in such an area or population. Pandemic- an international or worldwide epidemic of a specific health related event.

Related Questions

QUESTION 1 1. The relative importance or burden of a disease within a population will depend on a number of factors including : A. Disease frequency B. Disease severity C. Disease consequences D. All of the above

QUESTION 2 1 . With the epidemiologic transition, there is a reduction in malnutrition and _____ . A. Communicable diseases B. Injuries C. Non-communicable chronic diseases D. Mental health disorders

QUESTION 3 1. A major challenge to developing a burden of disease profile in low and middle-income countries relates to A. Unwillingness to share complete information B. Conflicting disease definitions C. Challenges obtaining information related to cause of death D. All of the above

QUESTION 4 1. The demographic transition describes which of the following changes to society A. Changes in birth and death rates that reflect a modern society B. Declines in mortality followed by a reduction in fertility C. A change in the age structure of the population D. All of the above

QUESTION 5 1. Measures of health status that combine mortality and morbidity data A. Facilitate comparisons both within and across populations B. Help estimate the quantitative health benefits from interventions C. Serve as tools to assist with resource allocation D. All of the above

QUESTION 6 1. The disability-adjusted life year is defined as A. A health gap population summary measure that combines time lost due to disability with that lost due to death B. A measure to compare the gap between the current situation to that of an ideal situation C. A measure that combines the amount of healthy life lost due to morbidity with that lost due to injury. D. Answers B and C

QUESTION 7 1. True or false? A key limitation to mortality-based indicators is that they fail to account for the morbidity caused by disease. True False

QUESTION 8 1. The most widely used composite measure of population health is the DALY, and this epidemiological measure is the sum of morbidity and ________data. A. Years of life lost (YLL) B. Morbidity C. Infant mortality rates (IMR) D. none of the above

QUESTION 9 1. What would be the best source of information on adult and infant mortality (in high income countries)? A. Disease registers B. Vital statistics C. Special survey study D. Hospital clinic statistics

QUESTION 10 1. Which term is best used to describe the proportion of people in a population who have a defined disease at a specific point of time? A. DALY B. Incidence C. Mortality rate D. Prevalence

QUESTION 11 1. Which term is best used to describe new cases of disease occurring in a population? A. DALY B. Incidence C. Mortality rate D. Prevalence

QUESTION 12 1. Which term is used to describe the absence or presence of illness or disease? A. Demography B. Morbidity C. Mortality D. Vitality

QUESTION 13 1. Mortality (death indicators) include: A. Mortality rate B. Infant mortality rate C. Neonatal morality rate D. All of the above

QUESTION 14 1. True or false? The value of life is often implicit in the way resource allocation decisions are made, which suggests that these decisions should be as explicit, open, and transparent as possible. True False

QUESTION 15 1. _________________is projected as the number one leading cause of disease burden in 2030. A. Ischemic heart disease B. Diabetes mellitus C. HIV/AIDS D. Unipolar depression

QUESTION 16 1. Some of the negative aspects of globalization include A. Greater insecurity of employment B. Poorer housing and sanitation due to rapid urbanization C. Greater vulnerability to environmental degradation D. All of the above

QUESTION 17 1. Current concerns about climate change focus on several developments including A. Rising global average land and sea surface temperature B. Increasing frequency of extreme weather conditions C. Both A and B D. None of the above

QUESTION 18 1. True or false? Diseases carried by mosquitoes are especially sensitive to meteorological conditions because they are vulnerable to changes in the ambient temperature. As a result of changing temperatures, infectious diseases such as malaria and dengue have decreased in incidence and geographic range. True False

QUESTION 19 1. True or false? International cooperation of infectious disease control has a long history that includes obligatory reporting of outbreaks of specific diseases. However, compliance with obligatory reporting has been poor due to economic consequences that have often accompanied notification of disease outbreaks. True False

QUESTION 20 1. True or false? Globalization is a relatively new phenomenon that began in the mid-20th century. True False

CASE STUDY

It used to be that epidemiologists at the CDC only knew that you had the flu when you visited your doctor and the doc- tor then reported that information to other agencies. By the time this information made its way to the CDC or state health departments, it was often several days old, which meant that the medical community was always playing catch-up. And of course, your doctor was only aware of your illness if you showed up at his office, not when you decided to tough it out at home. Nowadays, however, before you ever go to the doc- tor, you are likely to search the Internet for âflu symptoms,â tweet your suddenly declining health status, or Instagram yourself lying in bed. Study the case below, which shows how the Internet and social media have impacted the field of epi- demiology, and then answer the questions that follow.

Google Used to Predict Influenza Outbreaksâ2008

In 2008, Google launched Google Flu Trends, an applica- tion that compiles aggregated data from key word searches

for clinical terms, such as thermometer, chest congestion, muscle aches, or flu symptoms. Google reports the data on a website, which then provides an early-warning system for the locations of new flu outbreaks. Because the data are collected from searches performed each day, trends in flu symptoms become apparent much more quickly than when they are based on data reported during office vis- its or in lab reports from physicians around the country. When the CDC compared actual cases over the course of a year with Googleâs findings, the data from the two sources matched.

Initially, Google was only compiling information about flu trends in the United States and Canada. But after the H1N1 virus appeared in Mexico in 2009, the CDC asked Google to go back and look at Internet searches conducted by people in Mexico during that time. Evaluation of the data indicated that Google detected an uptick several days before the CDC did (Figure 23.1).

1,200 1,000 800 600 400 200 0

Influenza activity

1113151719212325272931 2 4 6 8 1012141618202224262830 2

Suspected Confirmed

Mar

Apr

May

Date of illness onset

Intense

High Moderate

Low Minimal

Jul Aug Sep

Oct Nov

Dec Jan

Feb Mar

Apr May Jun

Figure 23.1 2009 Inflenza activity (a) Data from the Centers for Disease Control, based on physical examination by health care providers, shows a peak in influenza cases in late April. (b) Google âFlu Trendsâ shows an influenza peak in February.

No. of cases

Case Study Exercise 23 Morbidity and Mortality Weekly Report 199

Epidemic tracking based on Internet searches reflects what is called collective intelligence. It works because indi- viduals using their personal computers tend to search for terms related to their immediate needs and intentions, and they generally do this before presenting in a doctorâs office or emergency room. The methodology used in the Google search was published in the prestigious science journal Nature, and another independent study has been published about a similar search analysis conducted by Yahoo, showing that it was effective in predicting flu trends.

Some people worry that data collected from Internet searches may compromise individualsâ privacy. However,

Google maintains that Flu Trends cannot be used to iden- tify individual users because the data are anonymous and are aggregated before being presented. Another potential drawback is that this data collection method is less likely to be useful for tracking epidemics in societies having a low percentage of computer ownership, namely, developing countries. However, considering the high stakes involved in identifying an epidemic quickly, Internet search term analy- sis holds great promise for public health. And, unlike most health innovations, itâs free!

3. How might data collected in this way not be representative of a particular population?

4. Explain why the two graphs in Figure 23.1 do not show influenza activity peaking at the same time.

6. In 2013, Google Flu Trends vastly overestimated the number of cases of the flu in the United States. One explanation for this was that there was a greater than usual number of media reports about influenza early in the flu season. Based on your knowledge of how Flu Trends works, explain why Google missed the mark in 2013

cyanyellowjacket531

Part II 1.The California Occupational Mortality study data set was employed to assess mortality data for the years 1979-1981. A 2% sample of employed persons from the 1980 census of California was used. It contains the occupation of each person who had died. This study, like any occupation-based study, is restricted to the work life span as far as age of subjects is concerned. This study used ages 16-64 years. Certain persons, because of their source of work, were excluded as subjects: homemakers, retired persons, students, disabled, military personnel, etc. Only main-stream-type employment was used in this study to establish occupations at risk for heavy alcohol drinking. Using the Table below, answer the following:

1.What occupations are most vulnerable to acquiring cirrhosis of the liver from heavy drinking?

2.List several of the occupations identified by the research studies that are more vulnerable to alcohol-induced, cirrhosis related deaths and that have the highest mortality rates.

3. What are possible confounding variables for the research in occupations and heavy drinking that lead to fatal diseases?

4. Based on available research data, develop and construct a web of causation along with the appropriate decision trees for occupational group-related alcohol deaths.

Table. Alcohol Related Deaths in California, 1979-1981 Cirrhosis 5.5% Digestive organ cancers 5.7% Injuries 13.7% Suicide and homicide 5.% All other causes 64.9% 2. Zika and microcephaly Since May 2015,

Brazil has experienced a significant outbreak of Zika virus. In recent years, Brazilian officials reported an increase in the number of babies born with microcephaly.

1. Briefly describe what we know and what we do not know about Zika virus.

2. What has been done and what should be done to prevent Zika virus epidemic in US and world-wide?

Multiple Choice

5. Which of the following statements describes the major advantages of a randomized clinical trial? a. It avoids observer bias b. It lends itself to ethical justification c. It yields results replicable in other patients d. It rules out self-selection of participants to the different treatment groups d. It enrolls representative patients

6. A survey conducted in England revealed that of 224 families in which there had been a known case of poliomyelitis, 56 maintained parakeets as a family pet. In another British survey, 30 out of 99 poliomyelitis patients questioned kept parakeets. The inference that there is some relationship between the presence of a parakeet in a household and the occurrence of poliomyelitis among household members is a. Correct b. Incorrect because of failure to distinguish between incidence and prevalence c. Incorrect because a proportionate ratio is used when a rate is required to support the inference d. Incorrect because a failure to recognize a possible cohort phenomenon e. Incorrect because there is no control or comparison group.

7. An investigator determines the correlation coefficient between triglyceride levels and degree of atherosclerosis in sampled blood vessels to be +1.67. On the basis of this you would conclude that: a. Triglyceride level is a good predictor of atherosclerosis b. Triglyceride level is not a good predictor of atherosclerosis c. High triglyceride levels cause atherosclerosis d. Atherosclerosis cause high triglyceride levels e. The investigator has incorrectly determined the correlation coefficient

8. A screening test of known sensitivity and specificity is applied to two populations. The prevalence of the disease being screened for is 10% in population A and is 1% in population B. Which of the following is true? a. The percent of all negative tests that have false-negative results is lower in population A than in population B. b. Specificity is lower in population A than in population B. c. Reliability is higher in population A than in population B. d. The percent of all positive tests that have false-positive results is lower in population A than in population B. e. Specificity is higher in population A than in population B.

9. Serum cholesterol levels are obtained for four healthy men. The probability that all will fall below the 10th percentile of the distribution of cholesterol for healthy males is: a. 0.4 b. 1 â (0.1)4 c. (0.1)4 d. (0.9)4 e. Cannot be determined from these data

10. In a diabetes screening program, the screening level for a positive blood sugar level in test 1 is set at 160 mg/dl, and in test 2 at 130 mg/dl. The sensitivity is: a. Greater in test 1 b. Greater in test 2 c. Equal in test 1 and 2 d. Dependent on the size of the population being evaluated

VIBS 204 Lecture Notes - Lecture 4: Salmonellosis, Kwashiorkor, Trichinella

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