VTPB 405 Lecture Notes - Lecture 16: Cytochrome P450, Ethambutol, Rifampicin
16 May 2020
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Isoniazid in latent tb can be used isolated 10 tb for 2 months. Rifampin induce cyp450 bind dna deep rna pot resistance can be used alone in liver injury. Cyp450 mutations prophylactic meningitis prophylactic monotherapy in close contact exposed to h influenzae. L excretion t other heptox drugs hepatitis when coadmin w produces orange body fluids. Bacteriostatic optic neuritis hyperuricemia hepatoxicity pyrazinamide unclear mech intracellular transferase l carb formation at cell wall t pyrazinoic acid in. 14 3 5mx n bacteriostatic when separate bacteriocidal. P aminobenzoic acid paba n 1st enzymatic step. 1st line in uti men treat acute prostitis i gram 0 g. Pyrimethamine co admin w folinic acid to avoid bone marrow side effects pancytopenia megaloblastic anemia. Teratogenic sulfa 0h14 allergic drug rxns fever rash anemia hemolytic anemia in g6pd def dash. Kerriicterus of displaces drugs inhibit cyp450 drug induced lupus. Acts on fungal cell membrane cell mem ergosterol not cholesterol makes.
