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Lecture 10

WFSC 301 Lecture Notes - Lecture 10: Rifampicin, Dapsone, ClofaziminePremium

2 pages34 viewsSpring 2017

Department
Wildlife & Fisheries Sci.
Course Code
WFSC 301
Professor
Walter Cook
Lecture
10

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Tuesday, February 28, 2017 at 3455 PM
Lecture 10: Leprosy “Hansen’s Disease”
Etiologic agent: Mycobacterium leprae
Acid Fast
gram positive
rod shaped - bacillus
multiplies quickly
Mostly found in Armadillos but also Humans
Can’t be given to domestic animals
Geographic Distribution:
Brought over by European immigrants to America
Thought to have originated in Africa
Most people affected are located in Africa, Asia and the Amazon
Mostly the SE area of USA
Signs:
2-5 years before serious symptoms
similar to syphilis and tetanus
Loss of temperature sensation
numbness
Skin lesion
growths on skin
muscle weakness - paralysis
6 classification of Leprosy:
Indeterminate
• Tuberculoid
• Borderline
Mid-borderline Turberculoid
Borderline Lepromatous
Lepromatous
Transmission
Transmitted through contact between cases of leprosy and healthy
persons
Transmission/contact isn’t completely understood though
95% of the population is immune to the bacteria*
Gross lesions
Macules or plaques - skin blemishes or scaly areas
• Pacuibacillary
- Asymmetrical
- numbness
- peripheral nerve enlargement
- Immune response
- immune cells attempt to seal off infection from the rest of
the body by surrounding pathogen
• Multibacillary
- Symmetrical
- stuffy nose
- Lion like face from inflammation
- blindness
- immune response
- No strong response - pathogen multiplies freely
Diagnosis
Skin Smear
Acid fast staining
Positive = rod shaped & red stained bacilli
Treatment
NO vaccine
Drugs to inhibit or eradicate growth:
- Dapsone
- Rifampicin
- Clofazimine
Multidrug therapy
Can take up to 6 - months to be cured
avoid contact with infected individuals
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