Class Notes (1,033,362)
US (405,781)
TAMU (5,670)
WFSC (34)
Lecture 10

WFSC 301 Lecture Notes - Lecture 10: Rifampicin, Dapsone, ClofaziminePremium

2 pages34 viewsSpring 2017

Wildlife & Fisheries Sci.
Course Code
WFSC 301
Walter Cook

This preview shows half of the first page. to view the full 2 pages of the document.
Tuesday, February 28, 2017 at 3455 PM
Lecture 10: Leprosy “Hansen’s Disease”
Etiologic agent: Mycobacterium leprae
Acid Fast
gram positive
rod shaped - bacillus
multiplies quickly
Mostly found in Armadillos but also Humans
Can’t be given to domestic animals
Geographic Distribution:
Brought over by European immigrants to America
Thought to have originated in Africa
Most people affected are located in Africa, Asia and the Amazon
Mostly the SE area of USA
2-5 years before serious symptoms
similar to syphilis and tetanus
Loss of temperature sensation
Skin lesion
growths on skin
muscle weakness - paralysis
6 classification of Leprosy:
• Tuberculoid
• Borderline
Mid-borderline Turberculoid
Borderline Lepromatous
Transmitted through contact between cases of leprosy and healthy
Transmission/contact isn’t completely understood though
95% of the population is immune to the bacteria*
Gross lesions
Macules or plaques - skin blemishes or scaly areas
• Pacuibacillary
- Asymmetrical
- numbness
- peripheral nerve enlargement
- Immune response
- immune cells attempt to seal off infection from the rest of
the body by surrounding pathogen
• Multibacillary
- Symmetrical
- stuffy nose
- Lion like face from inflammation
- blindness
- immune response
- No strong response - pathogen multiplies freely
Skin Smear
Acid fast staining
Positive = rod shaped & red stained bacilli
NO vaccine
Drugs to inhibit or eradicate growth:
- Dapsone
- Rifampicin
- Clofazimine
Multidrug therapy
Can take up to 6 - months to be cured
avoid contact with infected individuals
You're Reading a Preview

Unlock to view full version

Subscribers Only

Loved by over 2.2 million students

Over 90% improved by at least one letter grade.