BIOL 4376 Lecture Notes - Lecture 31: Cytomegalovirus Retinitis, Valganciclovir, Valaciclovir
3 Jul 2020
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Document Summary
Valacyclovir 1g po bid for 7-10 days. Reactivation in the immunocompromised state pneumonia, retinitis. People with good immune system don"t get these. Transmitted primarily through direct contact with infectious body fluids. Replicated in epithelial cells in the respiratory tract, salivary glands, and kidneys and persists in the lymphocytes. Not dependent on thymidine kinase for phosphorylation. Affects human cells a lot worse than acyclovir. Available iv and ocular gel for retinitis. Second line - reserved for cmv retinitis and acyclovir-resistant strains of. Does not require phosphorylation to be active. Last line - after patients fail cmv therapy with ganciclovir and foscarnet. Chills, fever, ha, rash, gi upset, anemia, neutropenia, renal toxicity. Moa: inhibits cmv replication by targeting cmv dna terminase complex. Lack of cross resistance with other antivirals. Cause of infectious mononucleosis and associated with certain cancers. Replication occurs in the epithelial cells or the surface of b lymphocytes of the pharynx and salivary glands.
