KINS 1224 Lecture Notes - Lecture 1: Mitosis, Cortisol, Chromatin

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23 Jan 2018
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Assumed role in physiological responses to light cycles. Possible role in mood disorders (sad, pms) 2 stored and secreted by the posterior pituitary. Stored in axon terminals of posterior pituitary. Only gland to store hormones in large quantity. Calcitonin produced by c or calcitonin cells. Major function help body cope with stress. Changing blood levels of ions and nutrients insulin/glucagon from pancreas. Cause effects on target cells through second messenger systems. Hormone binds to receptor (cid:1543) cascade of metabolic events. Cyclic amp: hormone (cid:1543) receptors, g-protein activated, g-protein activates ac, ac produces camp, camp activates pks, pks activates enzymes. Diacylglycerol and ip3: hormone (cid:1543) receptor, g-protein activated, g-protein activates phospholipase (pl, pl activates both, diacylglycerol - activates protein kinases, ip3 - ca++ into cell, binds to calmodulin activates protein kinases. (cid:1542) and (cid:1544) rates of cell processes. Result- low concentrations of a hormone can induce large effects. One hormone= thousands of enzyme molecules that initiates a cascade.

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