KINS 1224 Lecture Notes - Lecture 10: Arteriole, Sine Wave, Cardiac Output
16 Feb 2017
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Numerous mitotic divisions with cytokinesis: platelets form when cytoplasm breaks. Hemostasis: cessation of bleeding, hemostatic response. Quick, localized, carefully controlled: 3 mechanisms in microcirculation. Immediate contraction constrict vessel: decreases blood flow. Caused by: direct injury to vascular smooth muscle, chemicals from platelets and endothelial cells, local pain receptors. Temporary seal: damaged collagen fibers exposed, platelet adhesion occurs. Cascade of events: both lead to activation of factor x, many steps help to avoid premature clotting. Carry blood away from the heart: veins. Carry blood towards the heart: capillaries. Anatomy of blood vessles: tunica interna. Layer in contact with the blood: functions. Amount of smooth muscle varies: functions. Supplies blood to outer wall of large vessels. Arteries: designed to withstand surges of pressure, more smooth muscle, 3 categories. Intracellular clefts: small molecules pass through. Endothelial cells with filtration pores: greater permeability, rapid passage, no formed elements. Endothelial cells with large fenestrations: formed elements pass.
