NSG 3315 Lecture Notes - Lecture 14: Factor X, Autoimmune Disease, Anticoagulant
Document Summary
Multistep process that transforms blood into a semisolid clot with rbc"s trapped in the. Involves platelets, plasma clotting factors, anticoagulants, and blood vessel properties. Actually large fragments from the cytoplasm of bone marrow cells called megakaryocytic. Vitamin k is needed for synthesis of factors vii, ix, and x, prothrombin, and protein c. Calcium (factor iv) needed for all steps of the clotting process except the rst 2 steps. Anticoagulants (natural blood thinners = keep from clotting) Smoothness of the epithelial vessel lining prevents adherence of platelets and clotting factors during normal times. With vessel injury, the vessel contracts due to clotting factors. Immediate vasoconstriction of the vessel, which reduces blood ow. Release of factors such as txa2 (thomboxine a2) and nervous re exes help with vasoconstriction to not and bleed out. Platelet adhesion - platelets begin to adhere to injured sight must have von willebrand factor in order to have platelet adhesion.
