BIOL 201 Lecture Notes - Lecture 5: Nondisjunction, Karyotype, Genomic Imprinting

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Active genes, notably sry are responsible for masculine characteristics. Xy to develop as female: exceptions to chromosome theory of inheritance: Mitochondrial genes are inherited from female parent. (uniparentally) Leber"s hereditary optic neuropathy, defect in nad dehydrogenase subunit, results in reduced efficiency of electron flow through electron transport chain, leads to optic neural degeneration. Mothers pass to all children, whereas father with disease will not pass to any progeny. Chloroplasts genes are usually inherited from female parent. (uniparentally) Sum of the recombinants is divided by the total number of progeny is the recombination frequency. That number changed to %, is the cm or map units. Example: 433 phenotypes of one parent, 400 phenotypes of another parent, 78 are one mix of characteristic, and 89 are mix of other characteristic. Total progeny = 1000: dosage compensation: is the inactivation of one x chromosome early in embryonic development.

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