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Biology (196)
BIO-0013 (103)
Mc Vey (25)
Lecture

11-5-12.docx

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Department
Biology
Course
BIO-0013
Professor
Mc Vey
Semester
Fall

Description
11­5­12 • Using principles of genetic mapping to find disease genes o Millions of genetic differences have now been identified in our genomes o SNPs = single nucleotide polymorphisms o Ex: drug company wants to figure out why some people have more  adverse side effects when they take a certain drug  The C SNP appears to be tightly linked to the genetic locus that  determines whether or not an individual will have side effects  when taking the drug • Pedigree shows the inheritance pattern for a fictitious disease called Colbert  Syndrome o T SNP is linked to the mutant allele that causes Colbert syndrome o III­7 doesn’t have SNP but does have CS because recombination in II­5, G  SNP is now linked to CS mutant allele. (Allele crossed over onto G SNP) o Allele crossed off of T SNP in individual I­2, so II­3 does not have CS  SNPs are just indicators, not actual alleles • Incomplete dominance o Purple flower x white flower = lavender • Human blood types determined by glycoproteins o ABO blood type is an example of both multiple alleles and codominance  Type A = IAIA or IAi • can receive blood from A or O  Type B = IBIB or IBi • Can receive blood from B or O  Type AB = IAIB • Can receive A B AB O • Universal receiver  Type O = ii • Can receive O
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