Class Notes (834,153)
United States (323,640)
Biology (196)
BIO-0013 (103)
Mc Vey (25)
Lecture

10-9-12.docx

7 Pages
36 Views
Unlock Document

Department
Biology
Course
BIO-0013
Professor
Mc Vey
Semester
Fall

Description
10­9­12 • Frederick Griffith o Studied pneumonia bacteria o 2 types: rough and smooth o smooth has polysaccharide capsule that stops the immune system from  recognizing it o Transformation o Something from the smooth transferred to the rough to cause it to become  virulent • Avery, MacLeod, McCarty o Used protease, RNase, DNase o When DNase is used, no transformation • Hershey and Chase o Hereditary material of bacteriophages o capsid remains outside o labeled with P32 and S35  radioactive precursors o radioactive phages infect new bacteria o blender o centrifuge o ask: where are S35 and P32? • Franklin/Wilkins && Watson/Crick o Used Xray crystallography to deduce the structure of DNA  Crystallized molecule of DNA hit with Xray beam  Rays are diffracted onto film  Produces an image  Rosalind’s diffraction pattern • DNA double helix o Sugar phosphate backbone faces outwards o Nitrogenous bases face inwards o Right­handed helix o Wide major groove, narrow minor groove  o Base stacking on backbone allows for resonance of the electrons between  phosphate groups • Chargaff’s rules o Before the structure of DNA was known o Studied ratios of nucleic acids • Nucleic acids are composed of nucleotide building blocks o Ribose or deoxyribose
More Less

Related notes for BIO-0013

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit