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BIO-0013 (103)
Mc Vey (25)
Lecture

9-24-12.docx

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Department
Biology
Course
BIO-0013
Professor
Mc Vey
Semester
Fall

Description
9­24­12 • Signal hypothesis: Proteins must have something that directs them to the right  place o Proteins that enter the secretory pathway have a sequence of amino acids  at their N terminus that directs the nascent polypeptide to the ER, and  guides during translation into the lumen of ER o This sequence is the signal sequence or signal peptide  Signal sequence is made by ribosome  Sequence is recognized by SRP (signal recognition particle)  SRP binds to specific receptor on integral membrane protein  Allows protein to enter the lumen  Signal sequence is removed • Can be retained—protein is embedded in membrane of ER  (integral protein) • Proteins can be manually inserted through the membrane by ribosome o Requires GTP hydrolysis o The SRP and SRP receptor both bind and hydrolyze GTP to power the  opening of the translocon (purple thing) and insert the signal sequence into  the translocon • Secretory pathway o Protein enters ER while being synthesized by ribosome o Exits ER, travels to cis face of Golgi o Enters Gol
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